Well, this gives me hope.
Harry Potter and the Philosopher's Stone --
J.K. Rowling lived off government assistance and had to retype complete copies of this manuscript because she was too broke to have copies made. So she sent these copies off to publishers, where they were promptly rejected. The first several rejected it because it was simply too long of a story for a children's book.
Animal Farm by George Orwell --
Even though Orwell was a well-known author at this point, no one wanted to touch this story. Four publishers passed on it before it finally got published in 1945.
And to Think That I Saw It On Mulberry Street by Dr. Seuss --
Rejected by 27 publishers because it was just too different and silly.
Chicken Soup for the Soul --
This title was shopped around to 140 publishers; no one picked it up because it had a silly title, nobody wanted short stories, and there was no sex or violence in it.